The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis.

@article{Tian2014ThePO,
  title={The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis.},
  author={Bo Tian and Tao Jiang and Zhanying Shao and Zanjing Zhai and Haowei Li and Qiming Fan and Xuqiang Liu and Zhengxiao Ouyang and Tingting Tang and Qing Jiang and Minghao Zheng and Ke-rong Dai and A N Qin and Yongping Yu and Zhen-an Zhu},
  journal={Biomaterials},
  year={2014},
  volume={35 32},
  pages={8937-50}
}
Wear-particle-induced osteolysis leads to prosthesis loosening, which is one of the most common causes of joint-implant failure, a problem that must be fixed using revision surgery. Thus, a potential treatment for prosthetic loosening is focused on inhibiting osteoclastic bone resorption, which prevents wear-particle-induced osteolysis. In this study, we synthesized a compound named OA-14 (N-(3- (dodecylcarbamoyl)phenyl)-1H-indole-2-carboxamide) and examined how OA-14 affects titanium (Ti… CONTINUE READING

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