The prevention of osteoporotic progression by means of steroid loaded TCPL drug delivery systems.

@article{Scott2001ThePO,
  title={The prevention of osteoporotic progression by means of steroid loaded TCPL drug delivery systems.},
  author={Anthony D. Scott and Kent K. Higdon and Michelle A. Tucci and Hamed A. Benghuzzi and Aaron Puckett and Audrey Tsao and Zelma Cason and J M Lynne Hughes},
  journal={Biomedical sciences instrumentation},
  year={2001},
  volume={37},
  pages={13-8}
}
Numerous studies have suggested that there is a link between the age-related decreases in Estradiol and adrenal androgens, and the subsequent development of senile osteoporosis. The specific objectives of this investigation were: 1) to deliver Dehydroepiandrosterone (DHEA), Diosgenin (DG), and Estradiol (E) at sustained levels by Tri-Calcium Phosphate Lysine drug delivery systems (TCPL), and 2) to study the effects of the sustained delivery of DHEA, DG, and E on the bone turnover of adult… CONTINUE READING