The prevention of corticosteroid-induced bone loss with intermittent cyclical etidronate.

@article{Jenkins1999ThePO,
  title={The prevention of corticosteroid-induced bone loss with intermittent cyclical etidronate.},
  author={Elizabeth A Jenkins and Karen E Walker-Bone and Angela Wood and Fiona C McCrae and Claudette L Cooper and Michael I D Cawley},
  journal={Scandinavian journal of rheumatology},
  year={1999},
  volume={28 3},
  pages={152-6}
}
A prospective, randomised, double-blind, placebo controlled primary prevention trial was undertaken in 28 patients commencing low to moderate doses of corticosteroids for the first time. Patients were randomised to intermittent cyclical etidronate (400 mg daily for 2 weeks) and calcium (500 mg daily for 11 weeks) or intermittent cyclical placebo with calcium. After 52 weeks of treatment, lumbar spine BMD increased by 1.8% in the etidronate group, while it decreased by 3.7% in the placebo group… CONTINUE READING

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