The preventative role of antioxidants (selegiline and vitamin E) in a rat model of tardive dyskinesia.

@article{Sachdev1999ThePR,
  title={The preventative role of antioxidants (selegiline and vitamin E) in a rat model of tardive dyskinesia.},
  author={Perminder S. Sachdev and T Saharov and Stuart Cathcart},
  journal={Biological psychiatry},
  year={1999},
  volume={46 12},
  pages={1672-81}
}
BACKGROUND We examined the potential protective effects of two potent antioxidants, selegiline and vitamin E, in a rodent model of tardive dyskinesia (TD), viz. neuroleptic-induced spontaneous orofacial movements. METHODS Rats were treated with fortnightly injections of fluphenazine decanoate for 12 weeks, and examined at baseline and at fortnightly intervals for vacuous chewing movements, mouth tremors and tongue protrusions. RESULTS The administration of fluphenazine led to a progressive… CONTINUE READING
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