The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study

@article{Schmidt2009ThePO,
  title={The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study},
  author={Heather-Marie A Schmidt and S{\"o}nke Andres and Nadeem O Kaakoush and Lars Engstrand and Lena Eriksson and Khean-Lee Goh and K M Fock and Ida Hilmi and Subbiah Dhamodaran and David Forman and Hazel M Mitchell},
  journal={Gut Pathogens},
  year={2009},
  volume={1},
  pages={5 - 5}
}
BACKGROUND The putative H. pylori pathogenicity-associated factor dupA has been associated with IL-8 induction in vitro, and duodenal ulcer (DU) and gastric cancer (GC) development in certain populations, but this association is inconsistent between studies. We aimed to investigate dupA prevalence in clinical isolates from Sweden, Australia and from ethnic Chinese, Indians and Malays resident in Malaysia and Singapore and to examine the association with DU and GC. In addition we investigated… CONTINUE READING

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The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulcer in Belgium, South Africa, China or North America

  • RH Argent, A Burette, VY Miendje Deyi, JC Atherton
  • Clin Infect Dis
  • 2007
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