The prevalence of anticitrullinated protein antibodies increases with age in healthy individuals at risk for rheumatoid arthritis

@article{AlpizarRodriguez2017ThePO,
  title={The prevalence of anticitrullinated protein antibodies increases with age in healthy individuals at risk for rheumatoid arthritis},
  author={D Alpizar-Rodriguez and Laure Brulhart and Ruediger B. Mueller and Burkhard M{\"o}ller and Jean Dudler and Adrian Ciurea and Ulrich A. Walker and Ines Von M{\"u}hlenen and Diego Kyburz and Pascal Zufferey and Michael Mahler and Sylvette Bas and Danielle Gascon and C{\'e}line Lamacchia and Pascale Roux-Lombard and Kim Lauper and Michael J. Nissen and Delphine S. Courvoisier and Cem Gabay and Axel Finckh},
  journal={Clinical Rheumatology},
  year={2017},
  volume={36},
  pages={677-682}
}
  • D Alpizar-Rodriguez, Laure Brulhart, +17 authors Axel Finckh
  • Published in Clinical Rheumatology 2017
  • DOI:10.1007/s10067-017-3547-3
Transition from genetic risk to the development of systemic autoimmunity associated with rheumatoid arthritis (RA) is considered a key step for the development of RA and often referred to as the immune onset of the disease. The aim of this study is to identify predictors for the presence of anticitrullinated protein antibodies (ACPA) as a marker of systemic autoimmunity associated with RA in a high-risk population, an ongoing cohort of first-degree relatives of patients with RA. We assessed the… CONTINUE READING

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