The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies

  title={The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies},
  author={Xiaohong Li and Xiao-Mei Zhong and Li Lu and Wei Zheng and Shi-bin Wang and Wen-Wang Rao and Shuai Wang and Chee H. Ng and Gabor S. Ungvari and Gang Wang and Yutao Xiang},
  journal={Psychological Medicine},
  pages={583 - 594}
Abstract Background Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients. Methods A literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Prevalence estimates of agranulocytosis and… 

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  • 1998
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Neutropenia and Agranulocytosis in Chinese Patients Prescribed Clozapine.

  • K. LauP. H. Yim
  • Medicine, Psychology
    East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan
  • 2015
Long-term monitoring of white cell count is necessary during clozapine treatment and the concurrent use of clozAPine with other potentially leukopenic psychotropic drugs should be limited.

HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia.

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Blood dyscrasias in clozapine-treated patients in Italy.

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