The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.

@article{Howe2004ThePO,
  title={The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.},
  author={James R. Howe and Mamdouh Sayed and Abul Faiz Kabir Uddin Ahmed and John C. Ringold and Joy Larsen-Haidle and Anders Merg and Frank A. Mitros and Carlos Alberto Vaccaro and G. M. van Petersen and Francis M. Giardiello and Susan T. Tinley and Lauri A. Aaltonen and Henry T. Lynch},
  journal={Journal of medical genetics},
  year={2004},
  volume={41 7},
  pages={484-91}
}
BACKGROUND Juvenile polyposis (JP) is an autosomal dominant syndrome predisposing to colorectal and gastric cancer. We have identified mutations in two genes causing JP, MADH4 and bone morphogenetic protein receptor 1A (BMPR1A): both are involved in bone morphogenetic protein (BMP) mediated signalling and are members of the TGF-beta superfamily. This study determined the prevalence of mutations in MADH4 and BMPR1A, as well as three other BMP/activin pathway candidate genes in a large number of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy.

American journal of physiology. Gastrointestinal and liver physiology • 2012
View 10 Excerpts
Highly Influenced

Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome.

American journal of medical genetics. Part A • 2010
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…