The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

  title={The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia},
  author={Richard P. Allen and Sarah Auerbach and Huzefa Bahrain and Michael Auerbach and Christopher J. Earley},
  journal={American Journal of Hematology},
Restless Legs Syndrome (RLS) a common, under‐recognized disorder disrupts sleep and diminishes quality of life. Despite a clear relation between low peripheral iron and increased prevalence and severity of RLS, the prevalence and clinical significance of RLS in iron‐deficient anemic (IDA) populations is unknown. In this study all new patients referred for anemia to a community‐based hematology practice over a 1‐year period (March 2011–2012) were included if they had IDA and no RLS treatment… 

Correlates of Nonanemic Iron Deficiency in Restless Legs Syndrome

Iron deficiency without anemia (IDNA) is frequent in RLS and iron deficiency may be severe despite a normal hemoglobin level and women are at much higher risk for IDNA, and IDNA in women presents some specific clinical features.

Prevalence of restless legs syndrome among leprosy patients: a hospital based study.

The frequency of RLS among leprosy patients is significantly higher and they suffer from bad sleep quality at night which significantly affects their quality of life.

Restless legs syndrome/Willis–Ekbom disease prevalence in beta thalassemia patients

There was no presence of RLS among this sample of beta thalassemia patients from central Greece, and the adequate levels of iron and ferritin often seen in these patients could be the reason of the absence of R LS symptoms.

Restless legs syndrome in patients with chronic renal failure on hemodialysis: Does peripheral iron status matter?

Considering RLS, peripheral iron measures are of questionable validity in patients on hemodialysis, as RLS is known to cause impairment of daytime functioning, disturbed sleep, and increased mortality.

Iron treatment of restless legs syndrome

There is sufficient research to support the concept of altered brain iron homeostasis in RLS as part of the underlying pathology of RLS, and new iron treatment algorithms, based on evidence and consensus opinion have been developed.

Prevalence, severity, and impact on quality of life of restless leg syndrome in patients with liver cirrhosis in India

RLS was commoner in patients with LC than in controls, but did not correlate with liver disease severity and did not adversely influence QoL in LC.

Evaluation of Patients with Iron Deficiency Anemia

IDA affects sleep quality irrespective of psychological symptoms such as depression and anxiety, and Linear regression analysis showed no association between anxiety and depression with poor sleeping.

Restless leg syndrome a common undiagnosed comorbidity of clinical significance in cirrhosis

Child Turcotte Pugh Class and alcohol as etiology for liver dysfunction were significantly associated with RLS, and RLS has a clinical correlation with prognosis & severity of cirrhosis.



Iron deficiency anemia and restless legs syndrome: is there an electrophysiological abnormality?

Restless legs syndrome prevalence and impact: REST general population study.

Clinically significant RLS is common (prevalence, 2.7%), is underdiagnosed, and significantly affects sleep and quality of life.

Restless legs syndrome: understanding its consequences and the need for better treatment.

The role of iron in restless legs syndrome

  • R. AllenC. Earley
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2007
The data are presented documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms, and postulates combining dopaminergic and iron causes of RLS are presented.

Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents—The Peds REST Study

These population-based data suggest that restless legs syndrome is prevalent and troublesome in children and adolescents, occurring more commonly than epilepsy or diabetes.

Insight into the pathophysiology of restless legs syndrome

The relevance of CNS iron metabolism to the pathophysiology of RLS is discussed and a reduction in brain iron concentration occurs in RLS patients is suggested.

Prevalence and disease burden of primary restless legs syndrome: Results of a general population survey in the United States

The validated diagnostic tools and exclusion of medical conditions likely to cause RLS provide a very conservative estimate of US census‐weighted prevalence of 2.4% for primary RLS and 1.5% forPrimary RLS sufferers.