The prevalence and clinical profiles of FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations in a cohort of patients with de novo acute myeloid leukemia from southwest China

@article{Gou2015ThePA,
  title={The prevalence and clinical profiles of FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations in a cohort of patients with de novo acute myeloid leukemia from southwest China},
  author={Haimei Gou and J. Zhou and Yuanxin Ye and X. Hu and Mengqiao Shang and J. Zhang and Zhenzhen Zhao and W. Peng and Yanhong Zhou and Y. Zhou and X. Song and X. Lu and B. Ying},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={7357-7370}
}
  • Haimei Gou, J. Zhou, +10 authors B. Ying
  • Published 2015
  • Medicine
  • Tumor Biology
  • While a substantial amount of data on gene mutations related to acute myeloid leukemia (AML) prognosis from western and other populations have been reported, these studies largely describe one or two genes. Additionally, in southwest China, only insufficient data exist regarding FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations have been widely used in clinical settings. Therefore, a comprehensive study about these mutations of clinical importance in the prognosis of AML in western… CONTINUE READING
    9 Citations
    Mutational spectrum of acute myeloid leukemia patients with double CEBPA mutations based on next-generation sequencing and its prognostic significance
    • 15
    • Highly Influenced
    • PDF
    Laboratory Assays in Patients with Acute Promyelocytic Leukemia andFLT3-TKD Mutations
    • PDF
    Expression of the miR-148/152 Family in Acute Myeloid Leukemia and its Clinical Significance
    • Xiao-xue Wang, Rui Zhang, Y. Li
    • Medicine
    • Medical science monitor : international medical journal of experimental and clinical research
    • 2017
    • 5
    • PDF
    SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia
    • 4

    References

    SHOWING 1-10 OF 62 REFERENCES
    NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia
    • 9
    • Highly Influential
    Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia.
    • 299
    • Highly Influential
    • PDF
    Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis.
    • 1,536
    • Highly Influential
    • PDF
    Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
    • 53
    Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).
    • 637
    • Highly Influential
    • PDF