The preterm cervix reveals a transcriptomic signature in the presence of premature prelabor rupture of membranes

  title={The preterm cervix reveals a transcriptomic signature in the presence of premature prelabor rupture of membranes},
  author={S. Makieva and A. Dubicke and Sara F. Rinaldi and E. Fransson and G. Ekman‐Ordeberg and J. Norman},
  journal={American Journal of Obstetrics and Gynecology},
  • S. Makieva, A. Dubicke, +3 authors J. Norman
  • Published 2017
  • Medicine
  • American Journal of Obstetrics and Gynecology
  • BACKGROUND: Premature prelabor rupture of fetal membranes accounts for 30% of all premature births and is associated with detrimental long‐term infant outcomes. Premature cervical remodeling, facilitated by matrix metalloproteinases, may trigger rupture at the zone of the fetal membranes overlying the cervix. The similarities and differences underlying cervical remodeling in premature prelabor rupture of fetal membranes and spontaneous preterm labor with intact membranes are unexplored… CONTINUE READING
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