The presynaptic function of mouse cochlear inner hair cells during development of hearing.

@article{Beutner2001ThePF,
  title={The presynaptic function of mouse cochlear inner hair cells during development of hearing.},
  author={Dirk Beutner and Tobias Moser},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 13},
  pages={4593-9}
}
Before mice start to hear at approximately postnatal day 10, their cochlear inner hair cells (IHCs) spontaneously generate Ca(2+) action potentials. Therefore, immature IHCs could stimulate the auditory pathway, provided that they were already competent for transmitter release. Here, we combined patch-clamp capacitance measurements and fluorimetric [Ca(2+)](i) recordings to study the presynaptic function of IHCs during cochlear maturation. Ca(2+)-dependent exocytosis and subsequent endocytic… CONTINUE READING
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