The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells.

@article{Odemis2012ThePA,
  title={The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells.},
  author={Veysel Odemis and Jana Lipfert and Robert Kraft and Peter Hajek and Getu Abraham and Kirsten Hattermann and Rolf Mentlein and Juergen Engele},
  journal={Glia},
  year={2012},
  volume={60 3},
  pages={372-81}
}
SDF-1/CXCL12 binds to the chemokine receptors, CXCR4 and CXCR7, and controls cell proliferation and migration during development, tumorigenesis, and inflammatory processes. It is currently assumed that CXCR7 would represent an atypical or scavenger chemokine receptor which modulates the function of CXCR4. Contrasting this view, we demonstrated recently that CXCR7 actively mediates SDF-1 signaling in primary astrocytes. Here, we provide evidence that CXCR7 affects astrocytic cell signaling and… CONTINUE READING