The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.

@article{Hazra1998ThePO,
  title={The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.},
  author={Tapas K Hazra and Tadahide Izumi and L Maidt and Robert A. Floyd and Sankar A Mitra},
  journal={Nucleic acids research},
  year={1998},
  volume={26 22},
  pages={5116-22}
}
8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A, induces GC-->TA transversion mutations often observed spontaneously in tumor cells. The human cDNA encoding the repair enzyme 8-oxoG-DNA glycosylase (OGG-1) has… CONTINUE READING