The presence of sarcolipin results in increased heat production by Ca(2+)-ATPase.

@article{Mall2006ThePO,
  title={The presence of sarcolipin results in increased heat production by Ca(2+)-ATPase.},
  author={Sanjay Mall and Robert J. Broadbridge and Steven L Harrison and Michael G. Gore and Anthony G. Lee and J. Malcolm East},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 48},
  pages={36597-602}
}
Skeletal muscle sarcoplasmic reticulum of large mammals such as rabbit contains sarcolipin (SLN), a small peptide with a single transmembrane alpha-helix. When reconstituted with the Ca(2+)-ATPase from skeletal muscle sarcoplasmic reticulum into sealed vesicles, the presence of SLN leads to a reduced level of accumulation of Ca(2+). Heats of reaction of the reconstituted Ca(2+)-ATPase with ATP were measured using isothermal calorimetry. The heat released increased linearly with time over 30 min… CONTINUE READING

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