The presence of rRNA sequences in polyadenylated RNA and its potential functions

  title={The presence of rRNA sequences in polyadenylated RNA and its potential functions},
  author={Qiongman Kong and Michael P. Stockinger and Yueming Chang and Hirofumi Tashiro and Chien-Liang Glenn Lin},
  journal={Biotechnology Journal},
Accumulating evidence has shown that various lengths of ribosomal RNA (rRNA) sequences are widely present in polyadenylated RNA. This review article will discuss these polyadenylated rRNAcontaining transcripts (PART). PART are highly abundant and widely expressed in various tissues. It appears that there may be two types of PART. One type, type I, contains the rRNA segments (from ∼10 nucleotides up to several hundred nucleotides) located within the transcripts. It has been demonstrated that… 

Ribin-like proteins expression in the chaetognath Spadella cephaloptera

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Verified RNA preparations featured differentially modified tRNA populations whose information content allowed a distinction even among the related brain tissues cortex, cerebellum and hippocampus, and validated RNA preparations featuring differentiallymodified rRNA marker content that reflected the progress of intracellular RNA degradation after cell death.

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The authors' modeling suggests that these stretches can form single-strand stem loops, whose unpaired nucleotides could anneal to create an intramolecular kissing complex.

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The ribosome-first theory of cellular evolution proposes that cellular life evolved to facilitate the full potential of self-replicating ribosomes, and that genes evolved merely as storage units to “back up” ribosomal functions.

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Slide-seq provides a scalable method for obtaining spatially resolved gene expression data at resolutions comparable to the sizes of individual cells, and defines the temporal evolution of cell type–specific responses in a mouse model of traumatic brain injury.

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The variety of Earth’s organisms is manifold. However, it is the small-scale marine community that makes the world goes round. Microbial organisms of pro- and eukaryotic origin drive the carbon

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Ribosomal fragment abundance and presence of multiple viruses may prove to be useful diagnostic markers for colonies afflicted with CCD.

The Ribosome as a Missing Link in Prebiotic Evolution III: Over-Representation of tRNA- and rRNA-Like Sequences and Plieofunctionality of Ribosome-Related Molecules Argues for the Evolution of Primitive Genomes from Ribosomal RNA Modules

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rRNA-like sequences occur in diverse primary transcripts: implications for the control of gene expression.

  • V. MauroG. Edelman
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
The hypotheses that rRNA-like sequences may have spread throughout eukaryotic genomes and that their presence in primary transcripts may differentially affect gene expression are considered.

Intermolecular mRNA-rRNA hybridization and the distribution of potential interaction regions in murine 18S rRNA.

Computer analysis revealed 18S rRNA fragments complementary to oligonucleotides frequently met in mRNA, which are potential hybridization regions (clinger-fragments) and suggest a possible role of clinger-Fragments in translation processes as universal regions of mRNA binding.

rRNA-complementarity in the 5' untranslated region of mRNA specifying the Gtx homeodomain protein: evidence that base- pairing to 18S rRNA affects translational efficiency.

It is hypothesized that segments complementary to rRNA, such as those contained within the Gtx mRNA, form a category of cis-acting regulatory elements in mRNAs that affect translation by base pairing to r RNA within ribosomes.

Complementarity between ferritin H mRNA and 28 S ribosomal RNA.

Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro.

A number of site-directed mutations were introduced inRNA1 and RNA2 of B.subtilis RNA1 andRNA2 of domain V of Bacillus subtilis, taking clues from reports of these sites being involved in various steps of protein synthesis.

Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells.

In higher eukaryotes, translation of some mRNAs occurs by internal initiation. It is not known, however, whether this mechanism is used to initiate the translation of any yeast mRNAs. In this report,

An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes

The presence of the Gtx element in various m RNAs suggests that this element affects the translation of groups of mRNAs, and the possibility that other mRNA elements affect translation by base-pairing to different sites in the 18S rRNA is discussed.

A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity.

It is shown that increasing the number of copies of this IRES module in the intercistronic region of a dicistronic mRNA strongly enhances IRES activity in various cell lines, and parallels between IRES modules and transcriptional enhancer elements are suggested.