The presence of rRNA sequences in polyadenylated RNA and its potential functions

@article{Kong2008ThePO,
  title={The presence of rRNA sequences in polyadenylated RNA and its potential functions},
  author={Qiongman Kong and Michael P. Stockinger and Yueming Chang and Hirofumi Tashiro and Chien-Liang Glenn Lin},
  journal={Biotechnology Journal},
  year={2008},
  volume={3}
}
Accumulating evidence has shown that various lengths of ribosomal RNA (rRNA) sequences are widely present in polyadenylated RNA. This review article will discuss these polyadenylated rRNAcontaining transcripts (PART). PART are highly abundant and widely expressed in various tissues. It appears that there may be two types of PART. One type, type I, contains the rRNA segments (from ∼10 nucleotides up to several hundred nucleotides) located within the transcripts. It has been demonstrated that… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
rRNA-like sequences occur in diverse primary transcripts: implications for the control of gene expression.
  • V. Mauro, G. Edelman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
The hypotheses that rRNA-like sequences may have spread throughout eukaryotic genomes and that their presence in primary transcripts may differentially affect gene expression are considered. Expand
rRNA-like sequences in human mRNAs.
TLDR
This study indicates that mRNA sequences with long highly similar rRNA-like sequences are most likely artifacts, and analysis of the occurrence of 9-nt sequences covering the entire direct and complementary 18S human rRNA sequence revealed that many of them are significantly over- or underrepresented, suggesting their possible involvement in post-transcriptional regulation of gene expression. Expand
rRNA complementarity within mRNAs: a possible basis for mRNA-ribosome interactions and translational control.
TLDR
The ability of complementary sequences to bind to rRNA was investigated by using photochemical cross-linking and raised the possibility that direct base-pairing of particular mRNAs to rRNAs within ribosomes may function as a mechanism of translational control. Expand
Intermolecular mRNA-rRNA hybridization and the distribution of potential interaction regions in murine 18S rRNA.
TLDR
Computer analysis revealed 18S rRNA fragments complementary to oligonucleotides frequently met in mRNA, which are potential hybridization regions (clinger-fragments) and suggest a possible role of clinger-Fragments in translation processes as universal regions of mRNA binding. Expand
rRNA-complementarity in the 5' untranslated region of mRNA specifying the Gtx homeodomain protein: evidence that base- pairing to 18S rRNA affects translational efficiency.
TLDR
It is hypothesized that segments complementary to rRNA, such as those contained within the Gtx mRNA, form a category of cis-acting regulatory elements in mRNAs that affect translation by base pairing to r RNA within ribosomes. Expand
Leader sequence of a plant ribosomal protein gene with complementarity to the 18S rRNA triggers in vitro cap‐independent translation
TLDR
The ribosomal protein S18 (RPS18) leader mediated CIT was demonstrated by dicistronic constructs consisting of luciferase and chloramphenicol acetyl transferase reporter genes in an in vitro wheat germ extract system and was rapidly inhibited upon addition of an oligonucleotide that competed for the 18S rRNA site complementary to the RPS18C leader. Expand
Complementarity between ferritin H mRNA and 28 S ribosomal RNA.
TLDR
It is suggested that interaction of ferritin mRNA and 28 S RNA may function to regulate the stability and/or translatability of ferritein mRNA. Expand
Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro.
TLDR
A number of site-directed mutations were introduced inRNA1 and RNA2 of B.subtilis RNA1 andRNA2 of domain V of Bacillus subtilis, taking clues from reports of these sites being involved in various steps of protein synthesis. Expand
Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells.
  • W. Zhou, G. Edelman, V. Mauro
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
In higher eukaryotes, translation of some mRNAs occurs by internal initiation. It is not known, however, whether this mechanism is used to initiate the translation of any yeast mRNAs. In this report,Expand
An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes
TLDR
The presence of the Gtx element in various m RNAs suggests that this element affects the translation of groups of mRNAs, and the possibility that other mRNA elements affect translation by base-pairing to different sites in the 18S rRNA is discussed. Expand
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