The presence of midkine and its possible implication in human ovarian follicles.

@article{Hirota2007ThePO,
  title={The presence of midkine and its possible implication in human ovarian follicles.},
  author={Yasushi Hirota and Yutaka Osuga and Emi Nose and Kaori Koga and Osamu Yoshino and Tetsuya Hirata and Tetsu Yano and Osamu Tsutsumi and Sadatoshi Sakuma and Takashi Muramatsu and Yuji Taketani},
  journal={American journal of reproductive immunology},
  year={2007},
  volume={58 4},
  pages={367-73}
}
PROBLEM Ovarian follicles undergo a dynamic change to provide a mature ovum, and the process involves angiogenesis, follicular cell proliferation and leukocyte recruitment. Midkine (MK) is a heparin-binding growth factor that has angiogenic, mitogenic, and chemotactic activities. In the present study, we investigated the presence of MK and its possible role in human ovarian follicles. METHOD OF STUDY Follicular fluid (FF) and luteinized granulosa cells (LGC) were collected from women… CONTINUE READING