The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus.

@article{Lupo2008ThePO,
  title={The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus.},
  author={Patrizia Lupo and Yun C. Chang and Brian Lee Kelsall and Joshua M Farber and Donatella Pietrella and Anna Vecchiarelli and Francisca Le{\'o}n and Kyung J. Kwon-Chung},
  journal={Infection and immunity},
  year={2008},
  volume={76 4},
  pages={1581-9}
}
The aim of this investigation was to study the effect of polysaccharide capsule on the gene expression in dendritic cells (DC) during their interaction with Cryptococcus neoformans. To this end, we used an encapsulated virulent strain of C. neoformans and a cap59 gene-disrupted acapsular avirulent strain derived from the same genetic background. DC were exposed to encapsulated and acapsular C. neoformans strains for 4 h and 18 h, and their transcriptional profiles were analyzed using the… CONTINUE READING
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