The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER

@article{Neussert2010ThePO,
  title={The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER},
  author={Rudgar Neussert and Claudia Mueller and Vladimir M Milenkovic and Olaf Strauss},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2010},
  volume={460},
  pages={163-175}
}
Bestrophin-1, mainly analyzed in overexpression experiments, functions as Ca2+-dependent Cl– channel. Analysis of endogenously expressed bestrophin-1 suggested an influence on intracellular Ca2+. The aim of the study is to analyze the influence of endogenously expressed bestrophin-1 on Ca2+ homeostasis. Primary cultures of retinal pigment epithelial (RPE) cells were established from wild-type and bestrophin-1-deficient mice. Intracellular free Ca2+ ([Ca2+]i) was recorded by Ca2+ imaging… CONTINUE READING