The presence of 4-hydroxynonenal/protein complex as an indicator of oxidative stress after experimental spinal cord contusion in a rat model.

@article{Baldwin1998ThePO,
  title={The presence of 4-hydroxynonenal/protein complex as an indicator of oxidative stress after experimental spinal cord contusion in a rat model.},
  author={Susan A. Baldwin and Ryan Broderick and D Osbourne and Georg Waeg and Deborah A Blades and Stephen William Scheff},
  journal={Journal of neurosurgery},
  year={1998},
  volume={88 5},
  pages={874-83}
}
OBJECT The authors tested the hypothesis that breach of the blood-spinal cord barrier (BSCB) will produce evidence of oxidative stress and that a similar staining pattern will be seen between 4-hydroxynonenal (HNE)/protein complexes and extravasated immunoglobulin G (IgG). METHODS Adult female Fischer 344 rats, each weighing 200 to 225 g, were subjected to a spinal cord contusion at T-10 by means of a weight-drop device. Spinal cord tissue was assessed for oxidative stress by localizing… CONTINUE READING