The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study.

@article{Coxson2013ThePA,
  title={The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study.},
  author={Harvey O Coxson and Asger Dirksen and Lisa D. Edwards and Julie Carol Yates and Alvar Agust{\'i} and Per S. Bakke and Peter M. A. Calverley and Bartolome R Celli and Courtney C Crim and Annelyse Duvoix and Paola V Nasute Fauerbach and David A. Lomas and W. MacNee and Ruth J. Mayer and Bruce E. Miller and Nestor Luiz M{\"u}ller and Stephen I. Rennard and Edwin K. Silverman and Ruth Tal-Singer and Emiel F. M. Wouters and J\orgen Vestbo},
  journal={The Lancet. Respiratory medicine},
  year={2013},
  volume={1 2},
  pages={129-36}
}
BACKGROUND Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density. METHODS We used a random coefficient model to… CONTINUE READING
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