The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17.

@article{Bmer1996ThePT,
  title={The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17.},
  author={Ulf B{\"o}mer and Joachim Rassow and Nicole Zufall and Nikolaus Pfanner and Michiel Meijer and A. C. Maarse},
  journal={Journal of molecular biology},
  year={1996},
  volume={262 4},
  pages={389-95}
}
The preprotein translocase of the inner mitochondrial membrane has only been described in Saccharomyces cerevisiae to date. We report that the essential subunit Tim17 is highly conserved in evolution. The targeting and assembly of yeast Tim17 as well as that of human and Drosophila melanogaster Tim17 were characterized with isolated yeast mitochondria. Targeting signals in the mature protein direct the Tim17 precursors to the receptor Tom70 on the mitochondrial surface. In a membrane potential… CONTINUE READING

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