The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader.

@article{Shibata2009ThePO,
  title={The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader.},
  author={Yusuke Shibata and Makiko Fujii and Yuka Sugamura and Ryusuke Yoshikawa and Shinji Fujimoto and Sayaka Nakanishi and Yuya Motosugi and Naoya Koizumi and Masaki Yamada and Kiyohisa Ouchi and Yoshiteru Watanabe},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={365 1-2},
  pages={
          53-60
        }
}
A solid dispersion (SD) powder of indomethacin (IM) with CrosPVP was prepared continuously using a twin-screw extruder (extruder) or twin-screw kneader (kneader), which made it possible to simultaneously control kneading, mixing, and heating. For the extruder or kneader, IM existed in an amorphous state while it was treated with a screw rotation speed of 15 min(-1) or 50 min(-1), respectively, while being heated to 140 degrees C. IM and CrosPVP interacted to maintain IM in an amorphous state… Expand
Stability of amorphous indomethacin in a solid dispersion using crospovidone prepared by a twin-screw kneader or extruder and application of aqueous film-coating to solid dispersion tablets
A powder solid dispersion system (SD) of indomethacin (IM) with crospovidone prepared by a twin-screw kneader or twin-screw extruder possessed good fluidity and was suitable for tablet formulation.Expand
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