The preovulatory LH surge A case of a neuroendocrine switch.

  • I. J. Clarke
  • Published 1995 in Trends in endocrinology and metabolism: TEM


The preovulatory surge in LH is a unique endocrine event that involves a switch from the negative feedback effect of estrogen to a positive feedback effect. This occurs at both the level of the brain and that of the pituitary gland. Within the brain the mechanism appears to involve disinhibition of negative inputs to GnRH neurons, as well as stimulation of… (More)


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