The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine.

@article{Possemiers2006ThePI,
  title={The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine.},
  author={Sam Possemiers and Selin Bolca and Charlotte Grootaert and Arne Heyerick and Karel Decroos and Willem Dhooge and Denis de Keukeleire and Sylvie Rabot and Willy Verstraete and Tom Richard Van de Wiele},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 7},
  pages={1862-7}
}
Hops, an essential beer ingredient, are a source of prenylflavonoids, including 8-prenylnaringenin (8-PN), one of the most potent phytoestrogens. Because 8-PN concentrations in beers are generally low, its health effects after moderate beer consumption were considered negligible. However, human intestinal microbiota may activate up to 4 mg/L isoxanthohumol (IX) in beer into 8-PN. Depending on interindividual differences in the intestinal transformation potential, this conversion could easily… CONTINUE READING
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