The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.

@article{Zegher1995ThePR,
  title={The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.},
  author={Francis de Zegher and Flavia Pernasetti and Christine Vanhole and Hugo Devlieger and Greet Van den Berghe and Joseph A. Martial},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 11},
  pages={3127-30}
}
The role of thyroid hormone in the human fetus is uncertain; a significant amount of T4 is transferred from the maternal to the fetal circulation. A mother-infant pair was found to be heterozygotic for a point mutation in codon 271 of the gene encoding Pit-1, a pituitary-specific transcription factor regulating somatotrope, lactotrope, and thyrotrope function. At birth, serum T4 was undetectable in mother and infant. The newborn presented with a striking delay of respiratory, cardiovascular… CONTINUE READING

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