The premyofibril: evidence for its role in myofibrillogenesis.

@article{Rhee1994ThePE,
  title={The premyofibril: evidence for its role in myofibrillogenesis.},
  author={D Rhee and Jean M. Sanger and Joseph W. Sanger},
  journal={Cell motility and the cytoskeleton},
  year={1994},
  volume={28 1},
  pages={1-24}
}
When cardiac muscle cells are isolated from embryonic chicks and grown in culture they attach to the substrate as spherical cells with disrupted myofibrils, and over several days in culture, they spread and extend lamellae. Based on antibody localizations of various cytoskeletal proteins within the spreading cardiomyocyte, three types of myofibrils have been identified: 1) fully formed mature myofibrils that are centrally positioned in the cell, 2) premyofibrils that are closest to the cell… CONTINUE READING
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