The premenstrual period and exacerbations in multiple sclerosis.

  title={The premenstrual period and exacerbations in multiple sclerosis.},
  author={Anneke Zorgdrager and Jacques de Keyser},
  journal={European neurology},
  volume={48 4},
The aim of this study was to assess whether an association exists between the premenstrual period and exacerbations of multiple sclerosis (MS). The subjects were 56 premenopausal patients with relapsing MS and a regular menstrual cycle. Data over the previous 2 years were gathered from a structured MS database and a comprehensive questionnaire. 42% had exacerbations starting in the premenstrual phase. Within this group the proportion of premenstrual exacerbations was significantly higher than… CONTINUE READING

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