The prelimbic cortex muscarinic M₃ receptor-nitric oxide-guanylyl cyclase pathway modulates cardiovascular responses in rats.

@article{Fassini2015ThePC,
  title={The prelimbic cortex muscarinic M₃ receptor-nitric oxide-guanylyl cyclase pathway modulates cardiovascular responses in rats.},
  author={Aline Fassini and Leandro S Antero and Fernando Morgan de Aguiar Corr{\^e}a and S{\^a}mia Regiane Lourenço Joca and Leonardo B. M. Resstel},
  journal={Journal of neuroscience research},
  year={2015},
  volume={93 5},
  pages={830-8}
}
The prelimbic cortex (PL), a limbic structure, sends projections to areas involved in the control of cardiovascular responses. Stimulation of the PL with acetylcholine (ACh) evokes depressor and tachycardiac responses mediated by local PL muscarinic receptors. Early studies demonstrated that stimulation of muscarinic receptors induced nitric oxide (NO) synthesis and cyclic guanosine cyclic monophosphate (cGMP) formation. Hence, this study investigates which PL muscarinic receptor subtype is… CONTINUE READING