The prefrontal cortex in sleep

@article{Muzur2002ThePC,
  title={The prefrontal cortex in sleep},
  author={Amir Muzur and Edward F Pace-Schott and J. Allan Hobson},
  journal={Trends in Cognitive Sciences},
  year={2002},
  volume={6},
  pages={475-481}
}
View on Elsevier
bostonneuropsa.net
512 Citations
Highly Influential Citations
21
Background Citations
212
Methods Citations
14
Results Citations
16

Figures from this paper

512 Citations

Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex

Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States

TLDR
The hypothesis that delivery of cholinergic agonists – carbachol or nicotine – into prefrontal cortex of rat during slow wave sleep (SWS) would produce behavioral arousal and increase the time spent in wake state is tested and shows that unilateral microinjection ofcarbachol (1 mM) or nicotine (100 mM) into cortex during SWS decreased the latency to the onset of wake state and demonstrated a differential role of prefrontal cholinerg receptors in modulating spontaneous sleep-wake states.

Control of sleep and wakefulness.

TLDR
Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function.

The dreaming sleep stage: A new neurobiological model of schizophrenia?

The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation

TLDR
Functional magnetic resonance imaging was used to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency and individuals better able to maintain inhibitoryefficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness.

COGNITIVE PERFORMANCE IN SLEEP-DEPRIVED YOUNG VS. ELDERLY

1039 Double Dissociations Between Sleep Deprivation and Aging—Tucker et al While it is true that executive tasks involve the prefrontal cortex, they involve other areas of the brain as well.6 The…

Specific EEG Sleep Pattern in the Prefrontal Cortex in Primary Insomnia

TLDR
The present study shows a specific prefrontal sleep pattern during the whole sleep period and suggests that primary insomnia patients displayed a dysfunction in the reactivation of the limbic system during the REM sleep and gives additional arguments in favor of a sleep-protection mechanism displayed byPrimary insomnia patients.

Testing the involvement of the prefrontal cortex in lucid dreaming: A tDCS study

Frontal beta-theta network during REM sleep benefits you. matters

TLDR
These findings suggest that, counter to current prevailing thought, the DLPFC is active during REM sleep and likely interacting with other areas, and the dialogue between these two areas could play a role in the regulation of emotions and in procedural motor and emotional memory consolidation.

Assessing functioning of the prefrontal cortical subregions with auditory evoked potentials in sleep–wake cycle

...

References

SHOWING 1-10 OF 95 REFERENCES

Sleep deprivation-induced reduction in cortical functional response to serial subtraction.

TLDR
Data from the serial subtraction task are consistent with Horne's PFC vulnerability hypothesis but, based on this and other studies, it is suggested the localized, functional effects of SD in the brain may vary, in part, with the specific cognitive task.

Functional neuroanatomy of human rapid-eye-movement sleep and dreaming

TLDR
A group study of seven subjects who maintained steady REM sleep during brain scanning and recalled dreams upon awakening shows that regional cerebral blood flow is positively correlated with REM sleep in pontine tegmentum, left thalamus, both amygdaloid complexes, anterior cingulate cortex and right parietal operculum.

Human Sleep, Sleep Loss and Behaviour

  • J. Horne
  • Biology, Psychology
    British Journal of Psychiatry
  • 1993
The prefrontal cortex (PFC) consists of the cortex lying in front of the primary and secondary motor cortex, and includes the dorsolateral and orbital areas, frontal eye fields, and Broca's area. Not…

Sleep imaging and the neuro-psychological assessment of dreams

Dreaming and the brain: Toward a cognitive neuroscience of conscious states

TLDR
A three-dimensional model with specific examples from normally and abnormally changing conscious states of REM sleep dreaming is presented, suggesting that there are isomorphisms between the phenomenology and the physiology of dreams.

Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity

TLDR
Evidence is provided that short‐term sleep deprivation produces global decreases in brain activity, with larger reductions in activity in the distributed cortico‐thalamic network mediating attention and higher‐order cognitive processes, and is complementary to studies demonstrating deactivation of these cortical regions during NREM and REM sleep.

Forebrain activation in REM sleep: an FDG PET study 1 Presented in abstract form at the Society for Neuroscience Meeting, 1996. 1

Functional Neuroanatomy of Human Slow Wave Sleep

TLDR
The results show that rCBF is decreased more in some cortical areas (especially in orbitofrontal cortex) than in the rest of the cortex, and it is hypothesize that cellular processes taking place during SWS might be modulated differently in these regions.

Activity of Midbrain Reticular Formation and Neocortex during the Progression of Human Non-Rapid Eye Movement Sleep

TLDR
Selective deactivation of heteromodal association cortices, including those related to language, occurs with increasingly deep NREM sleep, which supports the recent theory that sleep is not a global, but it is a local process of the brain.

Dissociated pattern of activity in visual cortices and their projections during human rapid eye movement sleep.

TLDR
A model for brain mechanisms subserving REM sleep where visual association cortices and their paralimbic projections may operate as a closed system dissociated from the regions at either end of the visual hierarchy that mediate interactions with the external world is suggested.
...