The preferential beta3-adrenoceptor agonist BRL 37344 increases force via beta1-/beta2-adrenoceptors and induces endothelial nitric oxide synthase via beta3-adrenoceptors in human atrial myocardium.

@article{Pott2003ThePB,
  title={The preferential beta3-adrenoceptor agonist BRL 37344 increases force via beta1-/beta2-adrenoceptors and induces endothelial nitric oxide synthase via beta3-adrenoceptors in human atrial myocardium.},
  author={Christian Pott and Klara Brixius and Andreas Bundkirchen and Birgit Boelck and Wilhelm Bloch and Dirk Steinritz and Uwe Mehlhorn and Robert H. G. Schwinger},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 3},
  pages={521-9}
}
1 The present study investigated the effects of the preferential beta(3)-AR agonist BRL 37344 (BRL) on force of contraction (FOC), Ca(2+)-transient and eNOS-activity in human right atrial myocardium. 2 BRL concentration-dependently caused an increase in FOC that was paralleled by an increase in Ca(2+)-transient and a shortening of time to half peak relaxation (T0.5T). These effects were abolished in the presence of propranolol (0.3 micro M). 3 BRL acted as a competitive antagonist towards… CONTINUE READING

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