The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite.

@article{Wang2012ThePR,
  title={The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite.},
  author={Yan Wang and Thierry Aza{\"i}s and Marc Robin and Anne M J Vall{\'e}e and Chelsea Catania and Patrick Legriel and G{\'e}rard P{\'e}hau-Arnaudet and Florence Babonneau and Marie-Madeleine Giraud-Guille and Nadine Nassif},
  journal={Nature materials},
  year={2012},
  volume={11 8},
  pages={724-33}
}
The involvement of collagen in bone biomineralization is commonly admitted, yet its role remains unclear. Here we show that type I collagen in vitro can initiate and orientate the growth of carbonated apatite mineral in the absence of any other vertebrate extracellular matrix molecules of calcifying tissues. We also show that the collagen matrix influences the structural characteristics on the atomic scale, and controls the size and the three-dimensional distribution of apatite at larger length… CONTINUE READING
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