The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.

@article{Wells2010ThePW,
  title={The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.},
  author={Julie M. Wells and Miguel N. Rivera and Woo Jae Kim and Kristen Starbuck and Daniel A. Haber},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 7},
  pages={975-85}
}
WT1 encodes a tumor suppressor first identified by its inactivation in Wilms' Tumor. Although one WT1 splicing variant encodes a well-characterized zinc finger transcription factor, little is known about the function of the most prevalent WT1 isoform, whose DNA binding domain is disrupted by a three-amino acid (KTS) insertion. Using cells that conditionally express WT1(+KTS), we undertook a genome-wide chromatin immunoprecipitation and cloning analysis to identify candidate WT1(+KTS)-regulated… CONTINUE READING
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