The predictive accuracy of in vitro measurements for the dermal absorption of a lipophilic penetrant (fluazifop-butyl) through rat and human skin.

@article{Ramsey1994ThePA,
  title={The predictive accuracy of in vitro measurements for the dermal absorption of a lipophilic penetrant (fluazifop-butyl) through rat and human skin.},
  author={John D Ramsey and Bruce H. Woollen and Timothy R. Auton and Robert C. Scott},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1994},
  volume={23 2},
  pages={230-6}
}
The predictive accuracy of in vitro measurements in estimating dermal absorption has been evaluated in rat and human skin using fluazifop-butyl (FB), a lipophilic model compound, at dosage rates of 2.5, 25, and 250 micrograms/cm2. In vitro studies used rat and human epidermal membranes mounted in static diffusion cells with radiolabeled FB and receptor fluids of 50% aqueous ethanol (Aq Et), 6% polyethylene glycol 20 oleyl ether in saline (PEG), or tissue culture medium (TCM). In vivo rat… CONTINUE READING