The prediction of the dissolution rate constant by mixing rules: the study of acetaminophen batches.

@article{Lee2008ThePO,
  title={The prediction of the dissolution rate constant by mixing rules: the study of acetaminophen batches.},
  author={Tu En Lee and Hung Ju Hou and H. Y. Hsieh and Yan Chan Su and Yeh Wen Wang and Fu Bin Hsu},
  journal={Drug development and industrial pharmacy},
  year={2008},
  volume={34 5},
  pages={
          522-35
        }
}
The purpose of this article is to promote two simple and scalable methods to accelerate the formulation development of formulated granules using acetaminophen as a model system. In method I, formulated granules made from the batch of small particle-sized acetaminophen (1) by ball milling the batch of large particle-sized acetaminophen (2), and the mixture of the two batches at equal weights (mix) gave the dissolution rate constants (k) of k(1) = 0.43 +/- 0.15 minutes(-1), k(2) = 0.18 +/- 0.01… CONTINUE READING
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