The predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.

Abstract

Human somatostatin receptor subtype 5 (hSSTR5) regulates cell proliferation and hormone secretion. However, the identification of effective therapeutic small-molecule ligands is impeded because experimental structures are not available for any SSTR subtypes. Here, we predict the ensemble of low-energy 3D structures of hSSTR5 using a modified GPCR Ensemble… (More)
DOI: 10.1002/cmdc.201500023

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