The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences

@article{Kinniburgh1978ThePO,
  title={The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences},
  author={A. Kinniburgh and J. Mertz and J. Ross},
  journal={Cell},
  year={1978},
  volume={14},
  pages={681-693}
}
  • A. Kinniburgh, J. Mertz, J. Ross
  • Published 1978
  • Biology, Medicine
  • Cell
    • We have investigated the locations of the poly(A), the mRNA-specific sequences and the RNA sequences that are eventually cleaved from the 1860 nucleotide precursor of mouse beta-globin mRNA. Biochemical and electron microscopic data demonstrate that there are two intervening RNA moieties in the precursor which separate the beta-globin mRNA sequences into three portions containing 480, 205 and 155 nucleotides. One of the two intervening RNA moieties contains 780 nucleotides. The size of the… CONTINUE READING
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    References

    SHOWING 1-10 OF 36 REFERENCES
    The primary structure of rabbit β-globin mRNA as determined from cloned DNA
    • 284
    The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.
    • 155
    • PDF
    Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.
    • 99
    • PDF
    Purification and structural properties of the precursors of the globin messenger RNAs.
    • J. Ross
    • Biology, Medicine
    • Journal of molecular biology
    • 1978
    • 9
    Precursors of alpha and beta globin messenger RNAs.
    • 40
    Globin RNA precursor molecules: Biosynthesis and processing in erythroid cells
    • 128
    Purification of a putative precursor of globin messenger RNA from mouse nucleated erythroid cells.
    • S. Kwan, T. Wood, J. Lingrel
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1977
    • 50
    • PDF
    An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
    • 929
    • PDF
    Shortening of the poly(A) region of mouse globin messenger RNA.
    • 27
    A precursor of globin messenger RNA.
    • J. Ross
    • Biology, Medicine
    • Journal of molecular biology
    • 1976
    • 144