The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

@article{Kang1987ThePO,
  title={The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor},
  author={Jie Dr. Kang and H. Lemaire and Axel Dr Unterbeck and J. Michael Salbaum and Colin L. Masters and K. H. Grzeschik and Gerhard Multhaup and Konrad Beyreuther and Benno M{\"u}ller-Hill},
  journal={Nature},
  year={1987},
  volume={325},
  pages={733-736}
}
Alzheimer's disease1 is characterized by a widespread functional disturbance of the human brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles2 and extracel-lularly as amyloid plaque cores2 and in blood vessels2. The major protein subunit (A4) of the amyloid fibril of tangles, plaques and blood vessel deposits is an insoluble, highly aggregating small polypeptide of relative molecular mass 4,5003–6. The same polypep-tide is also deposited in the brains of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 74 CITATIONS, ESTIMATED 64% COVERAGE

FILTER CITATIONS BY YEAR

1988
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations