The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist.

@article{Bartolomeo2000ThePP,
  title={The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist.},
  author={A C Bartolomeo and Hugh Morris and Jerry J. Buccafusco and Nancy J Kille and Sharon J Rosenzweig-Lipson and M G Husbands and Annmarie L. Sabb and Magid A Abou-Gharbia and John A. Moyer and C A Boast},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 2},
  pages={584-96}
}
Muscarinic M1 preferring agonists may improve cognitive deficits associated with Alzheimer's disease. Side effect assessment of the M1 preferring agonist WAY-132983 showed significant salivation (10 mg/kg i.p. or p.o.) and produced dose-dependent hypothermia after i. p. or p.o. administration. WAY-132983 significantly reduced scopolamine (0.3 mg/kg i.p.)-induced hyperswimming in mice. Cognitive assessment in rats used pretrained animals in a forced choice, 1-h delayed nonmatch-to-sample radial… CONTINUE READING
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