The pre-history of hemocyanin. The discovery of copper in the blood of molluscs

@article{GhirettiMagaldi2005ThePO,
  title={The pre-history of hemocyanin. The discovery of copper in the blood of molluscs},
  author={Anna Ghiretti-Magaldi and Francesco Ghiretti},
  journal={Experientia},
  year={2005},
  volume={48},
  pages={971-972}
}
The presence of copper in molluscs was discovered in 1833 by Bartolomeo Bizio, a Venetian chemist, who found copper in marine gastropods of the family Muricidae during his studies on the purple dye he had isolated from these animals. Bizio was so surprised by this finding that he extended his analysis to several other invertebrate species in which he identified the metal. 

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References

SHOWING 1-4 OF 4 REFERENCES

Del rarne dei molluschi avutosi allo stato metallico

  • Annali Sci . Regno Lombardo Veneto

Das blaue Blut einiger wirbellosen Tiere und dessen Kupfergehalt

  • Arch . Anat . Physiol . wiss . Med .

Continuazione e fine delle investigazioni sopra il Murex brandaris . VI . Saggio per separare il tame dalle spire senza la preventiva cinefazione della materia

  • Annali Sci . Regno Lombardo Veneto

Scoperta del tame , oltreeh ~ nei murici , in vari altri generi e in varie altre specie di molluschi ; ed investigazioni cornprovanti l ' origine e lo stato del menzionato metallo in quegli esseri

  • Annali Sci . Regno Lombardo Veneto