The pre-history of hemocyanin. The discovery of copper in the blood of molluscs

  title={The pre-history of hemocyanin. The discovery of copper in the blood of molluscs},
  author={Anna Ghiretti-Magaldi and Francesco Ghiretti},
The presence of copper in molluscs was discovered in 1833 by Bartolomeo Bizio, a Venetian chemist, who found copper in marine gastropods of the family Muricidae during his studies on the purple dye he had isolated from these animals. Bizio was so surprised by this finding that he extended his analysis to several other invertebrate species in which he identified the metal. 

Molluscan hemocyanin: structure, evolution, and physiology

This review explains the molecular characteristics of molluscan hemocyanin mainly from the structural viewpoint, in which the structure of the functional unit, architecture of the huge cylindrical multimer, relationship between the composition of thefunctional unit and entire tertiary structure, and possible functions of the carbohydrates are introduced.

Bartolomeo Bizio and the rediscovery of Tyrian purple

The origin and chemical properties of Tyrian purple were first described in 1833 by Bartolomeo Bizio, a Venetian chemist. The work of Bizio on the red-purple dye is reported in a series of papers

Purification, caractérisation et étude des propriétés immunostimulantes de l'hémocyanine de crabe des neiges, chinoecetes opilio

Hemocyanin (He) from snow crab was purified from hemolymph by size-exclusion chromatography and characterized, revealing subunit heterogeneity and the presence of glycosidic linkages is undetectable with the periodic acid-Schiff base test.

Tyrian purple in archaeological textiles: DMF extraction and recrystallization for the Raman identification of precursors and derivatives

The prized ancient dyestuff, Tyrian purple, has been extensively and widely studied by multiple spectroscopic and chromatographic methods alike. In this paper, an extraction method adopted by liquid

Cosolvents Induced Unfolding and Aggregation of Keyhole Limpet Hemocyanin

The objective of this study was to examine the effects of 2,2,2 trifluoroethanol (TFE) and acetonitrile (ACN) on the stability, behavior, and structural characteristics of giant multimeric protein

Hemocyanins in the Immunotherapy of Superficial Bladder Cancer

Because the primary amino acid sequences of mollusk hemocyanins are highly divergent from mammalian sequences, they are strongly recognized by the immune system, resulting in potent immunogenicity; these proteins can be used therapeutically as non-specific immunostimulants with beneficial clinical outcomes.



Del rarne dei molluschi avutosi allo stato metallico

  • Annali Sci . Regno Lombardo Veneto

Das blaue Blut einiger wirbellosen Tiere und dessen Kupfergehalt

  • Arch . Anat . Physiol . wiss . Med .

Continuazione e fine delle investigazioni sopra il Murex brandaris . VI . Saggio per separare il tame dalle spire senza la preventiva cinefazione della materia

  • Annali Sci . Regno Lombardo Veneto

Scoperta del tame , oltreeh ~ nei murici , in vari altri generi e in varie altre specie di molluschi ; ed investigazioni cornprovanti l ' origine e lo stato del menzionato metallo in quegli esseri

  • Annali Sci . Regno Lombardo Veneto