The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms.

@article{Clark2005ThePC,
  title={The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms.},
  author={Marcus R. Clark and Adrian B Cooper and Leo D Wang and Iannis Aifantis},
  journal={Current topics in microbiology and immunology},
  year={2005},
  volume={290},
  pages={87-103}
}
B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine signaling (IL-7, stem cell factor, FLT3-L) is essential at this stage of development as it suppresses cell death, sustains proliferation and facilitates heavy chain rearrangements. As… CONTINUE READING
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