The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes

@article{Davies2004ThePO,
  title={The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes},
  author={D. Davies and W. Hol},
  journal={FEBS Letters},
  year={2004},
  volume={577}
}
The formation of transition state mimics of phosphoryl transfer reactions with the metal oxoanion vanadate is a powerful technique in macromolecular crystallography. The tendency of vanadate to form pentacovalent complexes exhibiting trigonal bipyramidal geometry makes this compound a close approximation of the transition state for such reactions. In many cases, vanadate complexes provide the most accurate visualization of the transition state that can be reasonably achieved. A survey of the… Expand
99 Citations
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