The power of identity-by-state methods for linkage analysis.

  title={The power of identity-by-state methods for linkage analysis.},
  author={D. Tim Bishop and John A. Williamson},
  journal={American journal of human genetics},
  volume={46 2},
The affected-sib-pair method has been widely utilized for mapping. This methodology is aimed at mapping complex traits which have been observed to be familial but for which Mendelian segregation, even after allowing for partial penetrance, is not apparent. Indications of linkage are based on the observation of nonrandom segregation at a marker locus in two affected siblings. We extend this methodology to more distant genetic relationships and examine the power of identity-by-state methods for… CONTINUE READING

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