The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility.

@article{Keimling2012ThePO,
  title={The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility.},
  author={Marlen Keimling and Miriam Deniz and Dominic Varga and Andreea Iulia Stahl and Hubert Schrezenmeier and Rolf Kreienberg and Isabell Hoffmann and Jochem K{\"o}nig and Lisa Wiesm{\"u}ller},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 5},
  pages={2094-104}
}
Most presently known breast cancer susceptibility genes have been linked to DSB repair. To identify novel markers that may serve as indicators for breast cancer risk, we performed DSB repair analyses using a case-control design. Thus, we examined 35 women with defined familial history of breast and/or ovarian cancer (first case group), 175 patients with breast cancer (second case group), and 245 healthy women without previous cancer or family history of breast cancer (control group). We… CONTINUE READING

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