The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.

@article{Mullarney2003ThePF,
  title={The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.},
  author={Matthew P. Mullarney and Bruno C. Hancock and Glenn T Carlson and Dauda D Ladipo and Beth A Langdon},
  journal={International journal of pharmaceutics},
  year={2003},
  volume={257 1-2},
  pages={227-36}
}
The physical, flow, and mechanical properties of four common pharmaceutical sweeteners were measured to assess their relative manufacturability in solid dosage formulations. Sucrose, acesulfame potassium (Sunett), saccharin sodium, and aspartame were evaluated to determine significant differences in particle shape, size distribution, and true density. Powder flow and cohesivity as well as compact mechanical properties such as ductility, elasticity, and tensile strength were measured and found… CONTINUE READING

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