The potential synergistic effect of calcium channel blockers and α-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion

  title={The potential synergistic effect of calcium channel blockers and $\alpha$-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion},
  author={Abdullah Al-Dohayan and Ali S. Al-Tuwaijri},
  journal={European Journal of Gastroenterology \& Hepatology},
Methods and results: Acute oral administration of various doses of α-tocopherol (100, 600, 1200mg/kg by mouth) produced a dose dependent and significant protection of mucosal injury induced by ischaemia-reperfusion injury in experimental animals. In addition, intraperitoneal administration of calcium channel blockers, nifedipine (0.5, 1, 3 mg/kg), diltiazem (1.25, 2.5 mg/kg) and verapamil (1.25, 2.5, 5, 10 mg/kg) protected gastric mucosa in ischaemia-reperfusion. α-Tocopherol (100 mg/kg by… 

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