The potential synergistic effect of calcium channel blockers and α-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion

  title={The potential synergistic effect of calcium channel blockers and $\alpha$-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion},
  author={Abdullah Al-Dohayan and Ali S. Al-Tuwaijri},
  journal={European Journal of Gastroenterology \& Hepatology},
Methods and results: Acute oral administration of various doses of α-tocopherol (100, 600, 1200mg/kg by mouth) produced a dose dependent and significant protection of mucosal injury induced by ischaemia-reperfusion injury in experimental animals. In addition, intraperitoneal administration of calcium channel blockers, nifedipine (0.5, 1, 3 mg/kg), diltiazem (1.25, 2.5 mg/kg) and verapamil (1.25, 2.5, 5, 10 mg/kg) protected gastric mucosa in ischaemia-reperfusion. α-Tocopherol (100 mg/kg by… 

Effect of Vitamin E on Aspirin-Induced Gastric Mucosal Injury in Rats

It is suggested that vitamin E protects against aspirin-induced gastric mucosal injury by inhibiting lipid peroxidation and accumulation of activated neutrophils.

Effects of alpha tocopherol and verapamil on liver and small bowel following mesenteric ischemia-reperfusion.

Both small bowel and liver injuries reperfusion, can be decreased by prophylactic use of alpha tocopherol and verapamil, and glutaminase activity in liver tissue can also be affected by small bowel ischemia-reperfusion.

Preventive effect of probiotics and α-tocopherol on ethanol-induced gastric mucosal injury in rats.

Probiotic mixture and α-tocopherol reduced ethanol-induced gastric mucosal lipid peroxidation, suggesting that they may be beneficial for gastric lesions induced by lower ethanol concentration.

Naloxone: a potent protective agent in ischemia ñ reperfusion ñ induced liver injury

SUMMARY Hepatic ischemia/reperfusion-induced injury is accompanied by free radical production, leading to endothelial cell destruction, adhesion of neutrophils and plugging of the hepatic sinusoids

The Protective Effects of Intravenous Anesthetics and Verapamil in Gut Ischemia/Reperfusion-Induced Liver Injury

Propofol may offer advantages by inhibiting lipid peroxidation and inflammatory cytokine production in an animal model of gut ischemia/reperfusion-induced liver injury and effectively stabilized the MDA levels and decreased the tissue injury scores of the liver and gut.

Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol.

The results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.

Effect of Nifedipine on the Healing of Left Colonic Anastomoses in Rats

Results clearly showed that nifedipine enhanced the stability of colonic anastomoses during the first postoperative week.

The effects of a - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion* intestinal iskemi/reperfüzyon sonrasinda a - tokoferol ve verapamilin mukozal fonksiyonlar üzerine etkisi

A- tocopherol is a promising agent for the prevention of tissue injury caused by free oxygen radicals during organ transplantation and also has preventive effects in organ preservation.

Oxidative Stress and Ischemia-Reperfusion Injury in Gastrointestinal Tract and Antioxidant, Protective Agents

  • M. SasakiT. Joh
  • Biology, Medicine
    Journal of clinical biochemistry and nutrition
  • 2007
The role of oxidant stress in the mechanism of I/R injury and the use of antioxidant agents for its treatment is focused on.

Monitoring dynamic alterations in calcium homeostasis by T1‐mapping manganese‐enhanced MRI (MEMRI) in the early stage of small intestinal ischemia–reperfusion injury

The data suggest that MnCl2 has the potential to be an MRI contrast agent that can be effectively used to monitor changes in intracellular Ca2+ homeostasis during the early stages of intestinal I/R injury.