The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target?

@article{Wang2012ThePR,
  title={The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target?},
  author={Li-Ling Wang and Yue Huang and Gang Wang and Shengdi Chen},
  journal={Medical hypotheses},
  year={2012},
  volume={78 3},
  pages={398-401}
}
Recently, there have been increasing evidences that microRNA-146 (miR-146) is related to up-regulated immune and inflammatory signaling through its target genes, such as IRAK1 and TRAF6. Additionally, abundant data continue to support the hypothesis that progressive up-regulation of inflammatory gene expression and elevated inflammatory signaling facilitate the development and progression of Alzheimer's disease (AD). This review focuses on the recent findings regarding the role of miR-146 in… CONTINUE READING