The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles.

Abstract

Aseptic loosening in total hip replacement is mainly caused by wear particles inducing inflammation and osteolysis. Wear can be a consequence of micromotions at the interface between implant and bone cement. Due to complex cellular interactions, different mediators (e.g. cytokines, proteinases) are released, which can promote osteolytic processes in the… (More)
DOI: 10.3892/ijmm.2011.778

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