The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.

@article{AbdelZaher2008ThePP,
  title={The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.},
  author={Ahmed Osman Abdel-Zaher and Randa H Abdel-Hady and Madeha M Mahmoud and Magda M Y Farrag},
  journal={Toxicology},
  year={2008},
  volume={243 3},
  pages={261-70}
}
The potential protective role of alpha-lipoic acid (alpha-LA) in acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity was investigated in rats. Pretreatment of rats with alpha-LA (100mg/kg) orally protected markedly against hepatotoxicity and nephrotoxicity induced by an acute oral toxic dose of APAP (2.5 g/kg) as assessed by biochemical measurements and by histopathological examination. None of alpha-LA pretreated animals died by the acute toxic dose of APAP. Concomitantly, APAP… CONTINUE READING