The potential of using hyperthermia to eliminate radioresistant hypoxic cells.

@article{Overgaard1991ThePO,
  title={The potential of using hyperthermia to eliminate radioresistant hypoxic cells.},
  author={Jens Overgaard and C. Grau and Jacob Chr Lindegaard and Michael Robert Horsman},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1991},
  volume={20 Suppl 1},
  pages={113-6}
}
It is known that cells in a nutritionally deprived and acidic environment are sensitive to heat. In general these same cells are chronically hypoxic and therefore heat possesses the potential to eliminate (some) of this radioresistant population. A direct radiosensitization is observed when heat is given simultaneously with radiation. This effect occurs to the same extent in both aerobic and hypoxic cells, thus the oxygen enhancement ratio is unchanged. By giving heat several hours after… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
FeverNo subtypeHypoxia
The potential of using hyperthermia to eliminate radioresistant hypoxic cells .
HypoxiaNo subtypeFever
The potential of using hyperthermia to eliminate radioresistant hypoxic cells .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
OxygenNo subtypeHypoxia
This effect occurs to the same extent in both aerobic and hypoxic cells , thus the oxygen enhancement ratio is unchanged .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
This effect could be further enhanced by adding hypoxic radiosensitizers ( nimorazole , misonidazole ) or a blood flow modifier ( nicotinamide ) which can eliminate acutely hypoxic cells .
HypoxiaNo subtypeOxygen
This effect occurs to the same extent in both aerobic and hypoxic cells , thus the oxygen enhancement ratio is unchanged .
The current investigation clearly demonstrates this concept in a C3H mammary carcinoma using a local tumor control assay .
All Topics